Exploring Diabetes Mellitus' Impact on Tuberculosis Outcomes: A Comprehensive Comparative Study
DOI:
https://doi.org/10.26911/jepublichealth.2025.10.02.03Abstract
Background: Tuberculosis (TB) remains among the top ten global causes of mortality, with approximately 1.3 million deaths annually. Diabetes elevates the risk of active TB and treatment failure, potentially increasing drug-resistant TB (DR-TB). This study aimed to compare treatment success rates between TB patients with and without diabetes mellitus (DM) at Dr. Ramelan Central Naval Hospital, Surabaya.
Subjects and Method: This cross-sectional study was conducted from January 2019 to December 2023 at Dr. Ramelan Central Naval Hospital Surabaya. A total of 158 patients with TB-DM and TB-NonDM were selected using total sampling. The independent variables were the Presence of Diabetes Mellitus in TB patients (TB-DM vs. Non-TB-DM). The dependent variable was the treatment success rate. The data were collected from patient medical records and analyzed using a chi-square test to compare treatment outcomes between TB-DM and TB-Non-DM patients.
Results: The analysis included 158 medical records. Predominantly affecting those over 45 years, both TB-DM and TB-Non-DM patients commonly underwent six months of treatment, with success rates of 78% in TB-DM and 82.4% in TB-Non-DM cases. The chi-square test yielded a p-value of 0.511, indicating no significant difference in treatment success between the groups. However, older age and HIV-positive status were associated with lower odds of treatment success.
Conclusion: Success rates were similar between the groups, showing no significant difference based on DM status. Despite similar success rates, older age and HIV-positive status were associated with lower odds of treatment success.
Keywords:
Infectious disease, tuberculosis, diabetes mellitus, therapeutic outcomesCorrespondence
Ronald Pratama Adiwinoto. Department of Community Medicine, Faculty of Medicine, Hang Tuah University. Jl. Gadung No.1, Jagir, Kec. Wonokromo, Surabaya, East Java, Indonesia, 60111. Email: adiwinoto.ronald@hangtuah.ac.id. Mobile: +62 878-511-9-1212.
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Published
2025-04-16
Issue
Vol. 10 No. 2 (2025)
Section
Articles
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