Risk Factors of Asthma among Adolescent and Adults: A Systematic Review Study and Meta-Analysis
Abstract
Background: Asthma is a global public health problem that affects the quality of life of patients and is associated with the number of deaths each year. Factors such as genetics, environment and behavior are believed to have a significant relationship to the development of asthma. This study aimed to identify risk factors for asthma in adolescents and adults.
Subjects and Method: This was a systematic review and meta-analysis with a search for articles published by the online database PubMed in 2016 to 2021. The dependent variable was asthma. The independent variables were several risk factors that influence diseases such as smoking, age, and others. Data were analyzed using RevMan software version 5.3.
Results: A subgroup analysis was conducted from 4 articles which stated that cardiovascular related There were a total of 12 articles analyzed in this study. Subjects who had allergic rhinitis (OR= 3.80; 95% CI= 1.65 to 8.77; p= 0.001) had a greater risk of developing asthma than those who did not. This also applies to subjects who smoke (OR= 1.53; 95% CI= 1.32 to 1.78; p= 0.001), live in urban areas (OR= 1.46; 95% CI= 1.13 to 1.89; p= 0.03), are female. (OR= 1.19; 95% CI= 0.91 to 1.55; p= 0.001).
Conclusion: Asthma is more susceptible to people who have allergic rhinitis, smoke, live in urban areas, are female.
Keywords: asthma, prevalence, risk factors.
Correspondence:
References
Aarab R, Vijverberg SJH, Prins M, Snijder MB, Ree RV, Fokkens WJ, Zwinderman AH, et al. (2019). Prevalence of and factors associated with adultonset asthma in different ethnic groups: The HELIUS study. Respir Med. 150: 113-119. doi: 10.1016/j.rmed.2019.02.018.
Agrawal S, Pearce N, Ebrahim S (2013). Prevalence and risk factors for self-reported asthma in an adult Indian population: a cross-sectional survey. Int J Tuberc Lung Dis. 17(2): 275-282. doi: 10.5588/ijtld.12.0438.
A
Avanzini MA, Ricci A, Scaramuzza C, Semino L, Pagella F, Castellazzi AM, Marconi M, et al. (2006). Deficiency of INF? Producing Cells in Adenoids of Children Exposed to Passive Smoke. Int J Immunopathol Pharmacol. 19(3): 609-616. doi: 10.1177/039463200601900317.
Barnes PJ Asthme. Harrison. (2012). Principes de M
Beasley R, Ellwood P, Asher I (2003). International patterns of the prevalence of pediatric asthma the ISAAC program. Pediatr Clin North Am. 50(3), 539
Beasley R, Semprini A, Mitchell EA (2015). Risk factors for asthma: is prevention possible? Lancet. 386(9998): 1075
Bousquet J, Mantzouranis E, Cruz AA, A
Bousquet J, Reid J, Weel CV, Baena Cagnani C, Canonica GW, Demoly P, Denburg J, et al. (2008). Allergic rhinitis management pocket reference 2008. Allergy. 63(8): 990
Bousquet J, Vignola AM, Demoly P (2003). Links between rhinitis and asthma. Allergy. 58(8): 691-706. doi: 10.1034/j.1398-9995.2003.00105.x.
Butland BK, Strachan DP, Rudnicka AR (2008). C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults. Eur Respir J. 32(1): 77
Chen Y, Dales R, Tang M, Krewski D (2002). Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol. 155(3): 191-197. doi: 10.1093/aje/155.3.191.
Cohen S, Dworetzky M, Frick OL (2003). Coca and Cooke on the classification of hypersensitiveness. J Allergy Clin Immunol. 111(1): 205
Eagan TML, Br
Ahmer ORE, Essery SD, Saadi AT, Raza MW,Ogilvie MM, Weir DM, Blackwell CC (1999). The effect of cigarette smoke on adherence of respiretory pathogens to buccal epithelial cells. FEMS Immunol. Med. Microbiol. 23(1):27-36. doi: 10.1111/j.1574695X.1999.tb01713.x.
Eklund LM, Irewall T, Lindberg A, Stenfors N (2018). Prevalence, age at onset, and risk factors of self-reported asthma among Swedish adolescent elite cross-country skiers. Scand J Med Sci Sports. 28(1): 180
Ferson M, Edwards A, Lind A, Milton G W, Hersey P (1979). Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects. Int J Cancer. 23(5): 603-609. doi: 10.1002/ijc.2910230504.
GAN (2014). The Global Asthma Report 2014. Retrieved from: http://globalasthmareport.org/2014/Global_Asthma_Report_2014.pdf.
Hagiwara E, Takahashi KI, Okubo T, Ohno S, Ueda A, Aoki A, Odagiri S, et al. (n.d.). Cigarette smoking depletes cells spontaneously secreting Th 1 Cytokines in the human airway. Cytokine. 14: 121-126. doi: 10.1006/cyto.2001.0860.
Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, et al. (2019). Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. The Lancet. 394(10196): 407-418. doi: 10.1016/S01406736(19)31147-X.
Idani E, Raji H, Madadizadeh F, Cheraghian B, Haddadzadeh S, Dastoorpoor M. (2019). Prevalence of asthma and other allergic conditions in adults in Khuzestan, southwest Iran, 2018. BMC Public Health. 19(1): 303. doi: 10.1186/s12889019-6491-0.
Karunanayake CP, Ami K, Abonyi S, Dosman JA, Pahwa P (2020). Prevalence and determinants of asthma among aboriginal adolescents in Canada. J Asthma. 57(1): 40
King ME, Mannino DM, Holguin F (2004). Risk factors for asthma incidence. A review of recent prospective evidence. Panminerva Med. 46(2): 97
Kirenga BJ, Jong CD, Katagira W, Kasozi S, Mugenyi L, Boezen M, Molen TVD, et al. (2019). Prevalence and factors associated with asthma among adolescents and adults in Uganda: a general population based survey. BMC Public Health. 19(1): 227. doi: 10.1186/s12889-019-6562-2.
Kumar P, Ram U (2017). Patterns, factors associated and morbidity burden of asthma in India. PloS One. 12(10): e0185938
Lawson JA, Rennie DC, Cockcroft DW, Dyck R, Afanasieva A, Oluwole O, Afsana J (2017). Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study. BMC Pulm Med. 17(1): 4. doi: 10.1186/s12890-016-0355-5.
Lin J, Wang W, Chen P, Zhou X, Wan H, Yin K, Ma L, et al. (2018). Prevalence and risk factors of asthma in mainland China: The CARE study. Respir Med. 137: 48
L
Ma Q, Yang T (2017). [Prevalence and influential factors for asthma among adults in Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 42(9): 1086
Mallol J, Crane J, Mutius EV, Odhiambo J, Keil U, Stewart A (2013). The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol (Madr). 41(2): 73-85. doi: 10.1016/j.aller.2012.03.001.
Martinez FD, Vercelli D (2013). Asthma. Lancet. 382(9901): 1360-1372. doi: 10.1016/S01406736(13)61536-6.
Mikuniya T, Nagai S, Tsutsumi t, Morita K, Mio T, Satake N, Izumi T (1999). Proinflammatory or regulatory cytokines released from HALF macrophages of healthy smokers. Respiration. 66(5): 419-426. doi: 10.1159/000029425.
Miller LG, Goldstein G, Murphy M, Ginns LC (1982). Reversible alterations in immunoregulatory T cells in smoking. Analysis by monoclonal antibodies and flow cytometry. Chest. 82(5): 526-529. doi: 10.1378/chest.82.5.526.
Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, et al. (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380(9859), 2197
Nyembue TD, Jorissen M, Hellings PW, Muyunga C, Kayembe JM (2012). Prevalence and determinants of allergic diseases in a Congolese population. Int Forum Allergy Rhinol. 2(4): 285-293. doi: 10.1002/alr.21017.
Obel KB, Ntumba KJM, Kalambayi KP, Zalagile AP, Kinkodi KD, Munogolo KZ (2017). Prevalence and determinants of asthma in adults in Kinshasa. PloS One. 12(5): e0176875
Ozoh OB, Aderibigbe SA, Ayuk AC, Desalu OO, Oridota OE, Olufemi O, Egbagbe E, et al. (2019). The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults. PloS One, 14(9): e0222281
Pullerits T, R
Putri SI, Widiyanto A, Fajriah AS, Atmojo JT, Akbar PS, Qomariah NL (2021). Health Education for the Prevention of Covid-19 Transmission with the 3M Movement in Ngaglik District, Batu City, East Java. Jurnal Empathy Pengabdian Kepada Masyarakat. 2(1): 57-62.
Shaaban R, Zureik M, Soussan D, Neukirch, C, Heinrich J, Sunyer J, Wjst M, et al. (2008). Rhinitis and onset of asthma: a longitudinal population-based study. Lancet. 372(9643): 1049
The International Union Against Tuberculosis and Lung disease, The International Study of Asthma and Allergies in Childhood (ISAAC), editors. (2014). The Global Asthma Report 2014.
Nieuwenhof LVD, Schermer T, Bosch Y, Bousquet J, Heijdra Y, Bor H, Bosch WVD, et al. (2010). Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma? Allergy. 65(8): 1049
Visness CM, London SJ, Daniels JL, Kaufman JS, Yeatts KB, Siega-Riz A-M, Liu AH, et al. (2009). Association of obesity with IgE levels and allergy symptoms in children and adolescents: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 123(5): 1163-1169. doi: 10.1016/j.jaci.2008.12.1126.
Wan J, Zhang Q, Li C, Lin J (2021). Prevalence of and risk factors for asthma among people aged 45 and older in China: a cross-sectional study. BMC Pulm Med. 21(1): 311. doi: 10.1186/s12890-021-01664-7.
Wang WY, Lin JT, Zhou X, Chen P, Wan HY, Yin KS, Ma LJ, et al. (2020). [A survey on clinical characteristics and risk factors of severe asthma in China]. Zhonghua yi xue za zhi. 100(14): 1106-1111. doi: 10.3760/cma.j.cn112137-20191117-02497.
Widiyanto A (2017). Hubungan Kepatuhan Minum Obat dengan Kesembuhan Pasien Tuberkulosis Paru BTA Positif di Puskesmas Delanggu Kabupaten Klaten (The Relationship of Compliance with Taking Medicines with Healing of Positive BTA Pulmonary Tuberculosis Patients at Delanggu Health Center, Klaten Regency). Interest: Jurnal Ilmu Kesehatan. 6(1): 7-12.
Widiyanto A, Atmojo JT, Darmayanti AT (2019). Pengaruh faktor kerawanan pangan dan lingkungan terhadap stunting (Effect of food insecurity and environmental factors on stunting). Interest: Jurnal Ilmu Kesehatan. 8(1): 61-66.
Widiyanto A, Handayani RT, Atmojo JT (2020). Issues, challenges, and potential of palliative care in pediatric nursing: A systematic review. J Matern Child Health. 5(1): 167-172. doi: 10.26911/thejmch.2020.05.02.06.
Widiyanto A, Handayani RT, Mahrifatulhijah M, Atmojo JT, Darmayanti AT (2019). The Canadian emergency department triage & acuity scale (CTAS) dan Perubahannya: A review. Avicenna: J Health Res. 2(2): 88-95. doi: 10.36419/avicenna.v2i2.311.
Widiyanto A, Murti B, Soemanto RB (2018). Multilevel analysis on the Socio-Cultural, lifestyle factors, and school environment on the risk of overweight in adolescents, Karanganyar District, Central Java. J Epidemiol Public Health. 3(1): 94-104. doi: 10.26911/jepublichealth.2018.03.01.08.
WHO (2008). The global burden of disease: 2004 update. Geneva, Switzerland: WHO, 2008. http://www.who.int/mediacentre/factsheets/fs307/en/index.html.
Zheng M, Wang X, Bo M, Wang K, Zhao Y, He F, Cao F, et al. (2015). Prevalence of allergic rhinitis among adults in urban and rural areas of china: a population-based cross-sectional survey. Allergy, Asthma & Immunology Research. 7(2): 148
