Meta Analysis the Effects of Asbestos and Silica Dust on the Risk of Lung Cancer among Workers
DOI:
https://doi.org/10.26911/jepublichealth.2022.07.02.12Abstract
Background: Lung cancer is a cancer whose incidence increases every year and is the number one cancer cause of death in the world. One of the causes of lung cancer comes from occupational exposure in the form of asbestos dust and silica. This study aims to analyze the effect of exposure to asbestos and silica dust on the incidence of lung cancer in the working community.
Subjects and Method: This study is a meta-analysis with the following PICO, population: working society. Intervention: exposure to asbestos dust and silica dust. Comparison: not exposed to asbestos dust and silica dust. Result: lung cancer. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. The keywords to search for articles were “dust exposure” OR “silica dust exposure” OR “asbestos dust exposure” OR “occupational dust exposure” AND “lung cancer”. The articles included are full-text English with a case-control study design from 2007 to 2022. The articles were selected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.
Results: A total of 14 case-control studies from continental Europe, America and Asia were selected for systematic review and meta-analysis. Based on 8 studies on the effect of exposure to asbestos dust on the incidence of lung cancer, the incidence of lung cancer increased 1.57 times compared to workers who were not exposed to asbestos dust (aOR= 1.57; 95% CI= 1.20 to 2.06; p= 0.001) and 9 case-control studies on the effect of exposure to silica dust showed an increase of 1.31 times the incidence of lung cancer compared to workers who were not exposed to silica dust (aOR = 1.31; 95% CI = 1.25 to 1.38; p<0.001).
Conclusion: Exposure to asbestos and silica dust increases the incidence of lung cancer in workers.
Keywords: asbestos, silica, occupational dust exposure, lung cancer.
Correspondence:
Aurina Firda Kusuma Wardani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Mobile: +6282135012135. Email: firdakw@gmail.com.
References
Barta JA, Powell CA, Wisnivesky JP (2019). Global epidemiology of lung cancer. Ann. Glob. Health. 85(1): 1–16. doi: 10.5334/aogh.2419.
Christian WJ, Huang B, Rinehart J, Hopen-hayn C (2011). Exploring geographic variation in lung cancer incidence in kentucky using a spatial scan statistic: Elevated risk in the appalachian coal-mining region. PHReports. 126(6): 789–796. doi: 10.1177/00333549-1112600604.
Craighead JE, Gibbs AR (2008). Asbestos and Its Diseases. Inggris: Oxford University.
De matteis S, Consonni D, Lubin JH, Tucker M, Peters S, Vermeulen RC, Kromhout H, et al. (2012). Impact of occupational carcinogens on lung cancer risk in a general population. Int. J. Epidemiol. 41(3): 711–721. doi: 10.1093/ije/dys042.
de Matteis S, Heederik D, Burdorf A, Colosio C, Cullinan P, Henneberger PK, Olsson A, et al. (2017). Current and new challenges in occupational lung diseases. ERR, 26(146): 1–15. doi: 10.1183/16000617.00802017.
Gaúcha R, Silva B, Maria L, Sarquis M (2020). Lung cancer related to occupational exposure: an integrative review. Rev Gaucha Enferm. 1–16. doi: 10.1590/19831447.2020.20190-378.
Ge C, Peters S, Olsson A, Portengen L, Schüz J, Almansa J, Behrens T, et al. (2020). Respirable crystalline silica exposure, smoking, and lung cancer subtype risks a pooled analysis of case-control studies. American Journal of Respiratory and Critical Care Medicine. 202(3): 412–421. doi: 10.1164/rccm.2019101926OC.
Guha N, Merletti F, Steenland NK, Altieri A, Cogliano V, Straif K (2010). Lung cancer risk in painters: A meta-analysis. Environ. Health Perspect. 118(3): 303–312. doi: 10.1289/ehp.0901402.
Hardt JS, Vermeulen R, Peters S, Krom-hout H, McLaughlin JR, Demers PA (2014). A comparison of exposure assessment approaches: Lung cancer and occupational asbestos exposure in a population-based case-control study. Occup Environ Med. 71(4): 282–288. doi: 10.1136/oemed-2013-101735.
Hogstedt C, Jansson C, Hugosson M, Tinnerberg H, Gustavsson P (2013). Cancer incidence in a cohort of Swedish chimney sweeps, 1958-2006. Am. J. Public Health. 103(9): 1708–1714. doi: 10.2105/AJPH.2012.300860.
Huh DA, Kang MS, Lee J, Choi JY, Moon KW, Lee YJ (2021). Occupational and environmental asbestos exposure and the risk of lung cancer in Korea: A case-control study in South Chung-cheong Province of Korea. PLoS ONE. 16(4): 1–11. doi: 10.1371/journal.pone.0249790.
Kachuri L, Villeneuve PJ, Parent ME, John-son KC, Harris SA (2014). Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men. IJC. 135(1): 138–148. doi: 10.1002/ijc.28629.
Lacourt A, Pintos J, Lavoué J, Richardson L, Siemiatycki J (2015). Lung cancer risk among workers in the construction industry: Results from two case-control studies in Montreal. BMC Public Health. 15(1): 1–11. doi: 10.1186/s12889-015-2237-9.
Lin HT, Liu FC, Wu CY, Kuo CF, Lan WC, Yu HP (2020). Epidemiology and survival outcomes of lung cancer: A population-based study. BioMed Res. Int. 2019. doi: 10.1155/2019/8148156.
Murti B (2018). Prinsip dan metode riset epidemiologi. Edisi ke 5. Surakarta: Program Studi Magister Ilmu Kese-hatan Masyarakat, Universitas Sebelas Maret.
Olsson A, Kromhout H, Agostini M, Hansen J, Lassen CF, Johansen C, Kjaerheim K, et al. (2010). A case-control study of lung cancer nested in a cohort of European asphalt workers. Environ. Health Perspect. 118(10): 1418–1424. doi: 10.1289/ehp.0901800.
Peters S, Vermeulen R, Portengen L, Olsson A, Kendzia B, Vincent R, Savary B, et al. (2016). SYN-JEM: A quantitative job-exposure matrix for five lung carcinogens. Ann Occup Hyg. 60(7): 795–811. doi: 10.1093/annhyg/mew034.
Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, López-Alfonso A, et al. (2020). COVID-19 and lung cancer: A greater fatality rate? Lung Cancer. 146: 19–22. doi: 10.1016/j.lungcan.2020.05.034.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Ca-Cancer J. Clin. 71(3): 209–249. doi: 10.3322/caac.21660.
Suraya A, Nowak D, Sulistomo AW, Icksan AG, Berger U, Syahruddin E, Bose-O’reilly S (2021). Excess risk of lung cancer among agriculture and construction workers in Indonesia. Ann. Glob. Health. 87(1): 1–14. doi: 10.5334/aogh.3155.
Suraya A, Nowak D, Sulistomo AW, Icksan AG, Syahruddin E, Berger U, Bose-O’reilly S (2020). Asbestos-related lung cancer: A hospital-based case-control study in Indonesia. Int. J. Environ. Res. 17(2): 1–10. doi: 10.3390/ijerph17020591.
Takala J (2015). Editorial: Eliminating occupational cancer. Ind. Health. 53(4): 307–309. doi: 10.2486/indhealth.53307.
Tse LA, Yu IS, Au JSK, Qiu H, Wang XR (2011). Silica dust, diesel exhaust, and painting work are the significant occupational risk factors for lung cancer in nonsmoking Chinese men. Br. J. Cancer. 104(1): 208–213. doi: 10.1038/sj.bjc.6606006.
Tse LA, Yu ITS, Qiu H, Au JSK, Wang XR (2012). Occupational risks and lung cancer burden for Chinese men: A population-based case-referent study. Cancer Causes Control. 23(1): 121–131. doi: 10.1007/s10552-011-9861-1.
Van Deurssen E, Meijster T, Oude Hengel KM, Boessen R, Spaan S, Tielemans E, Heederik D, et al. (2015). Effectiveness of a multidimensional randomized control intervention to reduce quartz exposure among construction workers. Ann Occup Hyg. 59(8): 959–971. doi: 10.1093/annhyg/mev-037.
Vida S, Pintos J, Parent MÉ, Lavoué J, Siemiatycki J (2010). Occupational exposure to silica and lung cancer: Pooled analysis of two case-control studies in Montreal, Canada. CEBP. 19(6): 1602–1611. doi: 10.1158/10559965.EPI-10-0015.
Villeneuve PJ, Parent MÉ, Harris SA, Johnson KC, Paulse B, Dewar R, Dryer D, et al. (2012). Occupational exposure to asbestos and lung cancer in men: Evidence from a population-based case-control study in eight Canadian provinces. BMC Cancer. 12. doi: 10.1186/1471-2407-12-595.
