Associations of Contact History, Smoking Status, Nutrition Status, Anti Retrovirus Treatment, and TB HIV Co-infection Among People with HIV/AIDS
Abstract
Background: Tuberculosis (TB) and HIV co-infection causes a heavy burden on health care systems and poses particular diagnostic and therapeutic challenges. Studies into predictors of TB-HIV co-infection is lacking in Indonesia. This study aimed to examine the associations of contact history, smoking status, nutrition status, ARV treatment, and TB HIV co-infection among people with HIV/AIDS (PLWH).
Subjects and Method: This was a unmatched case-control study conducted in Balige, North Sumatera. A sample of 82 people living with HIV/AIDS was selected for this study, comprising 41 cases with and 41 controls without TB-HIV co-infection. The dependent variable was TB-HIV co-infection. The independent variables were contact history, smoking status, nutrition status, and anti retroviral (ARV) treatment. The data on HIV/AIDS co-infection were taken from the medical record at HKBP Committee HIV/AIDS service. Other variables were measured by questionnaire. Data were analyzed by a multiple logistic regression.
Results: 82.9% of PLWH had no contact history with TB patients, 56.1% had poor nutrition status, 78% were smokers, and 58.5% had irregular ARV treatment. The risk of TB HIV co-infection increased with poor nutrition status (OR=3.48; p=0.014), smoking (OR=3.39; p=0.021), and irregular ARV treatment (OR=10.16; p<0.001). Test results multiple ARV treatment is the most dominant variable affecting the incidence of TB-HIV co-infection (OR= 8.04; 95% CI= 2.47 to 26.18; p<0.001).
Conclusion: The risk of TB HIV co-infection increases with poor nutrition status, smoking status, and irregular ARV treatment.
Keywords: TB, HIV co-infection, nutrition status, smoking, ARV treatment, people living with HIV/AIDS
Correspondence:
References
Br
Dwisarwa S, Nurlaela (2011). Merokok dan Tuberkuosis Paru (Studi Kasus do RS Margono Soekardjo Purwokerto).
Gelliespie, BamfordK (2007). Mikrobiolgi Medis dan Infeksi, Erlangga Medical Series, Jakarta.
Global report (2017).hiv/aids epidemic 2016, diakses oktober 2017, http://www.unaids.org/sites/default/files/media_asset/global-AIDS-update-2016
Global report (2017).koinfeksi tb/hiv epidemic, diakses oktober 2017 http://www.unaids.org/sites/default/files/media_asset/2017_data-book
Global report (2017). Progress report on HIV in the WHO South-East Asia Region 2016 http://apps.searo.who.int/PDS_DOCS/B5282
Kelemu TK, Alemayehu WY, Belaineh GB, Muuken MA (2013). Determinant factors Associated with Occurrence of Tuberculosis among Adult People Living with HIV after Antiretroviral treatment Initiation. Addis Ababa, Ethiopia. 8(5).
Kementerian Kesehatan Republik Indonesia(http://www.spiritia.or.id/Dok/juknistbhiv2013.pdf diakses pada 30 Oktober 2017).
Taha M, Amarew D, Tessema F, Assegid S, Duchateau L, Colebunders R (2013). Risk Factor of Actife Tuberculosis in People Living With HIV/AIDS in Southwest Ethiophia. 2: 131-139.
Mulugeta B, Bjune G,Abebe F (2015). Prevalence of tuberculosis, HIV, and TB-HIV coinfection among pulmonary tuberculosis suspects in a predominantly pastoralist area, northeast Ethiopia.
Pili K, Aboud S (2011). Tuberculosis HIV CoInfection among Patients Admitted at Muhimbili National Hospital in Dar es salaam, Tanzania.
Saputri RAS (20015). Faktor-faktor Koinfeksi TB Paru Pasien HIV/AIDS di Balai Kesehatan Paru Masyarakat Semarang.
